University of California, Irvine, 4311 Natural Sciences II - Bay 1 Irvine, CA 92697-2305  Bldg 402 

                                                                      Department of Developmental and Cell Biology

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Will human's someday regenerate limbs?
 

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Welcome

Welcome to the regeneration lab web site. Our goal is to keep the public informed on advancements in regenerative therapies and our latest findings. We hope you find this site interesting and educational

Dr. David M. Gardiner and Dr. Susan V. Bryant

       

      Dr. DAVID M. GARDINER
          Principle Investigator

Professor, Department of Developmental and Cell Biology
and Developmental Biology Center

Research Programs and Expertise

Molecular basis of pattern formation and growth control during limb development and regeneration. Developmental and molecular mechanisms underlying amphibian malformations in North America.Isolation and characterization of DNA and RNA, cDNA library construction and library screening, analysis of spatial and temporal patterns of gene expression, introduction and expression of transgenes in somatic cells, construction of retroviral expression vectors and retrovirus-mediated gene transfer, analysis of biological microstructure (histology, immunocytochemistry, and electron microscopy), cell culture, and microsurgery.

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                        Dr. SUSAN V. BRYANT                        
                           Principal Investigator

                   Vice Chancellor for Research
                 B.S., University of London, 1964
                Ph.D., University of London, 1967

Research

How to Regenerate a New Leg: What we can learn from salamanders.

Alone among vertebrates, urodele amphibians are able to regenerate lost body parts as adults. The key to this ability is that limb cells are triggered to dedifferentiate and reinitiate growth and pattern formation. Our strategy is to use axolotls (Ambystoma mexicanum) to discover the signals that trigger the regeneration response, in the belief that these signals have enormous potential and consequences for human health. Our long term goals are to identify the regeneration-enabling signals in limbs, in order to support progress towards the eventual application of these molecules to the improvement of human repair mechanisms. 
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                       Regeneration in the news

 April 2007 – Newt Limb Regeneration Movie. Produced by HHMI in a collaboration with Dr. David Gardiner.

November 2008 – Mexico City's 'water monster' nears extinction Click here

March 2007 – Edmonton Aging Symposium – Repairing the Damage Click here

November 2006 –Wnt signaling is important for limb regeneration Click here

April 2006 – Limb regeneration in the New York Times Click here

May 2006 – UCI researchers receive $3.9 million grant to focus on wound healing
DARPA Grant

© University of California Irvine 2006

                     Rapid wound healing model

                 Double click on image to start movie

In the Axolotl, a 2 mm wound heals in less than 10 hours, in the mammal a 2 mm wound heals in 2 to 3 days. Understanding this process may lead to rapid wound healing in mammals. >>Read more >>